Daily Trends Now
Daily Trends Now


New Human Organ Holds a 5th of Body's Fluid

New Human Organ Holds a 5th of Body's Fluid

Called the interstitium, it consists of a series of fluid-filled, shock-absorbing compartments that shield body tissues. "For a body part to officially become an organ, a consensus would need to develop around the idea as more researchers study it", study author Dr. Neil Theise, a professor of pathology at New York University Langone School of Medicine, told Live Science.

Scientists report on their identification of a previously undetected, but widespread, structural feature in the human body that could play a key role in how tissues and organs function, and also impact on disease mechanisms and spread.

The press release states: "Importantly, the finding that this layer is a highway of moving fluid may explain why cancer that invades it becomes much more likely to spread".

To start to understand the function of the new organ the team designed a new method of tissue examination that involves the freezing of biopsy tissue, which helps preserve the anatomy of the organ.

Schematic of the fluid-filled space supported by a network of collagen bundles lined on one side with cells. For instance, scientists always knew that 20 percent of body fluids was missing in a total tally, in between blood, lymph, serum and other bodily fluids.

When slides were examined that's what it looked like, because to make a slide the fluid is drained away as part of the process.

Co-authors of the study David Carr-Locke and Petros Constantinos Benias have first encountered interstitium in 2015 while they investigate a bile duct from a cancer patient. Once the team recognized this new space in images of bile ducts, they quickly recognized it throughout the body, wherever tissues moved or where it was compressed by force.

The fluid-filled tissue is also though to act as a shock absorber for the body. Upon further scrutiny, they determined that the lattice is composed of collagen bundles that support fluid-filled spaces and are lined irregularly with flattened cells that produce two markers, one endothelial and one mesenchymal.




In his opinion, the interstitium acts as a source of lymph, the fluid vital to the functioning of immune cells and which carries infection-fighting white blood cells.

"This has both", he said of the interstitium, per CNN.

"This discovery will open up new research pathways for inflammation and cancer progression".

The new organ contains strong (collagen) and flexible (elastin) connective tissue proteins.

Called a "probe-based confocal laser endomicroscopy", or pCLE, it allows a microscopic view of living tissue. It has been identified in connective tissues, including those just below the surface of the skin.

For their latest studies, the team used a freezing technique to prepare surgically obtained tissue specimens from cancer patients in such a way that the interstitial compartments weren't disrupted.

The organ's true objective was finally discovered during a routine endoscopy looking at a patient's bile duct.

This fluid layer that surrounds most organs may explain why cancer spreads so easily. Researchers said interstitium could significantly advance the understanding of cancer and many other diseases.

follow

editors' picks

March 28, 2018
Israel detains armed Palestinians who breached Gaza border
The machinery was damaged but did not catch fire, and the attackers fled back into Gaza, she said. The Israeli army was checking reports of the firings and a spokesman declined immediate comment.

March 27, 2018
U.S. sends China to-do list to cut trade imbalances
White House officials said the actions came after years of efforts failed to convince China to change its behaviour. Dozens of trade groups sent a letter to the president on Sunday urging Trump to pursue a different course.

March 26, 2018
Sergio Garcia rallies on back nine to advance at Match Play
A win in the Round of 16 will boost the Englishman into the top 50 in the world and save him a spot at the Masters in two weeks. The other semifinal will pit Alex Noren against Kevin Kisner.

March 25, 2018
Woman accused of injecting children with meth, letting men sexually assault them
A crowd of men and boys watched as she collapsed unconscious after the shocking beating in Bulandshahr , Uttar Pradesh. The video , which contains violent content and may be disturbing for some viewers, is now available on YouTube.

March 24, 2018
Woman bumped from overbooked United flight walks away with $10K
However, she was reportedly kept from boarding the flight because there was not room and she paid the lowest fare for her ticket. A spokesman for United Airlines confirmed on Friday that a passenger got the big voucher, but he didn't name the person.

March 22, 2018
Gonzaga vs. Florida State - 3/22/18 College Basketball Pick, Odds, and Prediction
"We were much better than Xavier in the last two and a half minutes of the game", Florida State Coach Leonard Hamilton said. Because Florida State doesn't win this game without PJ Savoy - another of our favorites - doesn't do his thing.

March 21, 2018
Sensex loses 3300-mark ahead of US Fed meet
The National Stock Exchange (NSE) benchmark index Nifty shed 45 points to touch 10,049 on the downside. Tata Steel, Adani Ports, Tata Motors and Infosys were among the top gainers, rising up to 3 percent.

March 21, 2018
Google launches news initiative to combat fake news
Google in a blog post accepts that it is "becoming increasingly hard to distinguish what's true (and not true) online ". Early tests show that customers who used Google Shopping Actions bought an average of 20 percent more items.

March 20, 2018
Supreme Court upholds Pennsylvania election map in win for Democrats
There are few legal options left for Republicans in the state. "These are things that, on the present record, we can not do". The Supreme Court case seemed to be state Republicans' last realistic chance to preserve the current map of 18 U.S.

March 19, 2018
Pak 'must do more' against Taliban, terror groups
Earlier, Pakistan embassy in Washington hosted a luncheon in honour of Prime Minister Shahid Khaqan Abbasi. The meeting lasted for 40 minutes.